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Ademola AYELESO

Research Professor
college of AGRICULTURE, ENGINEERING AND SCIENCE (COAES)
Biochemistry Programme

Research Professor of Biochemistry at Bowen University, Iwo, Nigeria, and an Academic Associate in the Department of Life and Consumer Sciences, University of South Africa, South Africa. I have successfully supervised five PhD and four MSc students. I am a prolific writer with about forty-nine publications. I am also a member of some notable professional bodies and an alumnus of a Nobel laureates meeting in Medicine/ Physiology held in Germany in 2011. I have taught several courses in biochemistry at both undergraduate and postgraduate levels. I have also had some years of experience as a Postdoctoral Research Fellow in South Africa and served as an editor for three books on medicinal plants.

Education
  • Ph.D (Biomedical Technology) Biomedical Sciences, Cape Peninsula University of Technology (2013)
  • M.Sc (Biochemistry) University of Port Harcourt (2007)
  • B.Tech (Applied Biochemistry) Federal University of Technology, Akure, (2002)
Research

Research interest focuses on the therapeutic use of medicinal plants, plant products and synthesized compounds in the management of metabolic diseases particularly diabetes mellitus and obesity. In addition, I also investigate the molecular mechanisms through which these agents exhibit their health promoting effects.

Institutional Service
  • Research Professor of Biochemistry at Bowen University
  • Director of Research and Strategic Partnerships in Bowen University
  • Ag. Director of the Office of Research, Grants and Linkages (2018-2022)
Professional Service
  • Academic Associate in the Department of Life and Consumer Sciences, University of South Africa, South Africa
  • Ag. Head of the Department of Biochemistry (2018-2021) in Adeleke University
    • Actively participated in national and international scientific conferences such as;
  • 49th Congress of the Physiological Society of Southern Africa, Stellenbosch University, South Africa, 2022. Paper presented (oral): In-vitro and in-vivo Antioxidative effect of Hydroethanolic Allium sativum Extract on High Fat Diet-induced Oxidative Stress in Drosophila Melanogaster
  • African Scholar Seminar at the College of Agriculture and Environmental Sciences, University of South Africa, 2022. Paper presented (oral): Potentials of garlic (Allium sativum) in the control of feeding behaviour in Drosophila melanogaster: A molecular docking approach.  
  • 1st International Conference, Faculty of Science, Adeleke University, Nigeria, 2022. Paper presented (oral): The use of Drosophila Melanogaster as a model for human diseases.
  • 23rd Indigenous Plant Use Forum (IPUF), South Africa, 2021 (Virtual). Paper presented (oral): Protective effects of hydro-ethanolic seed extract of Monodora tenuifolia on high sucrose-induced diabetes in Drosophila melanogaster (Fruit flies).
  • Inaugural toxicology conference, University of Ibadan, Ibadan, Nigeria, 2020. Paper presented (Poster): Anti-obesity potential of rutin in fruit flies fed with high fat diet.
  • 47th Congress of the Physiological Society of Southern Africa, East London, South Africa, 2019. Paper presented (Oral): Impact of oleanolic acid on heart inflammation in high fructose-fed neonatal Sprague-Dawley rats.
  • Joint Congress of the South African Society of Biochemistry and Molecular Biology (SASBMB) and the Federation of African Societies of Biochemistry and Molecular Biology (FASBMB), South Africa, 2018. Paper presented (Oral): Potentials of S-allyl-cysteine on the modulation of inflammatory responses in high fructose-induced metabolic dysfunction in growing male Wistar rats.
  • 45th Congress of the Physiological Society of Southern Africa, University of Pretoria, South Africa, 2017. Paper presented (Oral): Free radical scavenging ability of improved thiosemicarbazone-triazole hybrids and their influence on genes related to diabetes mellitus.
  • 2nd International Conference and Expo on Lipids: Metabolism, Nutrition and Health, Orlando, USA, 2016. Paper presented (Oral): Influence of calmodulin dependent protein kinase (CaMK)II on lipid droplets in rat skeletal muscle and its relevance to mitochondria function.
  • Indigenous Plant Use Forum (IPUF), Eastern Cape, Soutth Africa, 4th – 6th July, 2016. Paper presented (Poster): Rooibos (Aspalathus linearis) and its modulatory roles on antioxidant status in some common health problems: A review. 
  • International conference on Targeting Diabetes and Novel Therapeutics, Las Vegas, USA, 2015. Paper presented (Oral): Novel hybrid compounds from thiosemicarbazone and triazole as antidiabetic agents and their antioxidant potentials.
  • African Society for Laboratory Medicine Conference, Cape Town, South Africa, 2014. Paper presented (Poster): Effects of co-administration of red palm oil and rooibos on glycaemic and liver function parameters in streptozotocin-induced diabetic rats.
  • International Research Congress on Integrative Medicine and Health, Portland, USA, 2012. Paper presented (Poster): Influence of dietary red palm oil on antioxidant status in male Wistar rats.
Selected Publications
  1. Oyenihi, O, George, T, Oyenihi, A, Omotola, EO, Ojo, O, Ayeleso, A, Oguntibeju, O. (2023). Health and commercial relevance of Garcinia species: Key scientometric analyses from three decades of research: Garcinia species: Scientometric analyses of their health and commercial values. Plant Science Today. https://doi.org/10.14719/pst.2396
  2. Ojo, OA, Ogunlakin, AD, Gyebi, GA, Ayokunle, DI, Odugbemi, AI, Babatunde, DE, Ajayi-Odoko OA, Iyobhebhe, ME, Ezea, SC, Akintayo, OC, Ayeleso, AO, Ojo, AB, Ojo, OO (2023). GC-MS chemical profiling, antioxidant, anti-diabetic, and antiinflammatory activities of Ethyl Acetate Fraction of Spilanthes filicaulis (Schumach. & Thonn.) C.D. Adams Leaves: Experimental and Computational Studies. Frontiers in Pharmacology, 14:1235810. https://doi.org/10.3389/fphar.2023.1235810.
  3. Nzekwe, S, Morakinyo, A, Ntwasa, M, Oguntibeju, O, Oyedapo, O, Ayeleso, A. (2023). Influence of flavonoid-rich fraction of Monodora tenuifolia seed extract on blood biochemical parameters in streptozotocin-induced diabetes mellitus in male Wistar rats. Metabolites, 13(2):292. https://doi.org/10.3390/metabo13020292.
  4. Adegbola, MV, Anyim, G, Ntwasa, M, Ayeleso, AO, Oyedepo, TA. (2022). Potential effect of Syzygium aromaticum (Cloves) extract on serum antioxidant status and lipid profiles in Wistar rats with artesunate toxicity. Applied Science, 2022, 12, 8216. https://doi.org/10.3390/app12168216. 
  5. Oyebamiji, AK, Soetan, EA, Akintelu, SA, Ayeleso, AO, Emmanuel Mukwevho, E. Alpha-glucosidase activity of phytochemicals from Phyllanthus amarus leaves via in-silico approaches. Pharmacological Research – Modern Chinese Medicine, 2: 100054. https://doi.org/10.1016/j.prmcm.2022.
  6. Aderemi, AV, Ayeleso, AO, Oyedapo, OO, Mukwevho, E. (2021). Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases. Metabolites,11, 418. https://doi.org/10.3390/metabo11070418
  7. Ajayi L, Ayeleso A, Oyedepo T, Mukwevho E. (2021). Ameliorative Potential of Hydroethanolic Leaf Extract of Parquetina nigrescens on d-Galactose-Induced Testicular Injury. Molecules, 26(11):3424. https://doi.org/10.3390/molecules26113424
  8. Ayeleso AO, Matumba MG, Ntambi JM, Mukwevho E (2020). Insights into the metabolism of lipids in obesity and diabetes in Lipid Signaling and Metabolism by Elsevier, 1st Edition). Published by Academic Press, Pages 345-357, ISBN: 9780128194041. https://doi.org/10.1016/B978-0-12-819404-1.00017-8
  9. Mosana, M, Ayeleso, A, Nyakudya, T, Erlwanger, K, Mukwevho E. (2020). Potential protective effects of neonatal supplementation with oleanolic acid on peroxisome proliferator-activated receptor gamma (PPARγ) igand dependent regulation of glucose homeostasis in high fructose-fed rats. Natural Product Communications 15(3): 1-7. https://doi.org/10.11771934578X20913747
  10. Ayeleso, A, Adepoju, A, Mukwevho, E. (2019). Nuclear Respiratory Factor-1 (NRF-1), a versatile therapeutic target: influence of plant metabolites. African Journal of Biomedical Research, 23, 1-8 https://www.ajol.info/index.php/ajbr/article/view/202129
  11. Ayeleso, AO, Lembede, BW, Nyakudya, TT, Adepoju, AE, Chegou, NN, Mukwevho, E. (2020). Neonatal administration of S-allyl cysteine modulates inflammatory biomarkers in high-fructose fed rats. Tropical Journal of Pharmaceutical Research,19(5):1053-1058. doi: http://dx.doi.org/10.4314/tjpr.v19i5.21
  12. Nyakudya, TT, Isaiah, S, Ayeleso, A, Ndhlala, AR, Mukwevho, E, Erlwanger, KH. (2019). Short-term neonatal oral administration of oleanolic acid protects against fructose-induced oxidative stress in the skeletal muscles of suckling rats. Molecules, 24(4), 661 doi: https://doi.org/10.3390/molecules24040661
  13. Matumba, MG, Ayeleso, AO, Nyakudya, T, Erlwanger K, Cheguo, NN, Mukwevho E. (2019). Long term impact of neonatal intake of oleanolic acid on the expression of amp-activated protein kinase, adiponectin and inflammatory cytokines in rats fed with high fructose diet. Nutrients, 11(2), 226. https://doi.org/10.3390/nu11020226
  14. Ayeleso, AO, Joseph, JS, H, Oguntibeju, O, Mukwevho, E (2018). Evaluation of free radical scavenging capacity of methoxy containing-hybrids of thiosemicarbazone-triazole and their influence on glucose transport. BMC Pharmacology and Toxicology 19:84. https://doi.org/10.1186/s40360-018-0266-6
  15. Ajuwon, OR, Ayeleso, AO, Adefolaju, GA. The potential of South African herbal tisanes, rooibos and honeybush in the management of type 2 diabetes mellitus. Molecules 2018, 23, 3207. doi: 10.3390/molecules23123207
  16. Molepo, M, Ayeleso, A, Nyakudya, T, Erlwanger, K, Mukwevho, E (2018). A study on neonatal intake of oleanolic acid and metformin in rats (Rattus norvegicus) with metabolic dysfunction: implications on lipid metabolism and glucose transport. Molecules, 23(10), 2528; https://doi.org/10.3390/molecules23102528
  17. Joseph, JS, Ayeleso, AO, Mukwevho, E (2018). Importance of CaMKII activation in the regulation of adiposomes and ATP production in rat skeletal muscle. Transactions of the Royal Society of South Africa. 73(2): 193-197 https://doi.org/10.1080/0035919X.2018.1476421
  18. Ayeleso, AO, Joseph, JS, Belay, YH, Mazibuko, SE, Kinfe, H, Oguntibeju, O, Mukwevho, E (2017). Novel hybrid compounds from thiosemicarbazone and triazole as antidiabetic agents and their antioxidant potentials. Biomedical Research. 28(1): 411-420 https://www.alliedacademies.org/articles/hybrid-compounds-from-thiosemicarbazone-and-triazole-as-antidiabetic-agents-and-their-antioxidant-potentials.html
  19. Joseph JS, Ayeleso, AO, Mukwevho, E (2017). Exercise increases hyper-acetylation of histones on the cis-element of NRF-1 binding to the Mef2a promoter: Implications on type 2 diabetes. Biochemical and Biophysical Research Communications. pii: S0006-291X(17)30441-2
  20. Ayeleso, A, Kazeem, MI, Ayeleso, T, Mukwevho, E (2017). Phytochemistry and anti-oxidative effects of Aspalathus linearis herbal tea: A review in Developing Technologies of Food Science. Edited by Murlidhar Meghwal and Megh R. Goyal, CRC Press, Taylor & Francis Group, pp 319-331, ISBN: 978-1-77188-448-8.
  21. Joseph JS, Ayeleso AO, Mukwevho E (2017). Role of exercise-induced calmodulin protein kinase (CAMK)II activation in the regulation of omega-6 fatty acids and lipid metabolism enzymes in rat skeletal muscle. Physiological Research, 66(6):969-977. Doi: https://doi.org/10.33549/physiolres.933509
  22. Ayeleso, A, Brooks, N, Oguntibeju, O, Mukwevho, E (2016). Natural Antioxidant Vitamins: A review of their beneficial roles in management of diabetes mellitus and its complications. Tropical Journal of Pharmaceutical Research. 15 (6): 1341-1348. Doi: https://doi.org/10.4314/tjpr.v15i6.30
  23. Oyenihi AB, Ayeleso AO, Mukwevho E, Masola B (2015). Antioxidant strategies in the management of diabetic neuropathy. BioMed Research International, Volume 2015, Article ID 515042, 15 pages, http://dx.doi.org/10.1155/2015/515042.
  24. Ayeleso AO, Oguntibeju, OO, Brooks, NL (2015). Impact of co-administration of red palm oil (Elaeis guineensis Arecaceae) and rooibos (Aspalathus linearis Fabaceae) on glycaemic parameters, liver function and key glycolytic enzymes in diabetic rats. Trop J Pharm Res. 14:1613–1619. http://dx.doi.org/10.4314/tjpr.v14i9.10
  25. Kazeem, MI, Ayeleso AO, Mukwevho E (2015). Olax subscorpioidea Oliv. Leaf alleviates postprandial hyperglycaemia by inhibition of α-amylase and α-glucosidase International Journal of Pharmacology ISSN 1811-7775. DOI: 10.3923/ijp.
  26. Ayeleso, AO, Oguntibeju, OO, Brooks, NL (2014). Invitro study on the antioxidant potentials of the leaves and fruits of Nauclea latifolia. The Scientific World Journal, Article ID 437081, doi:10.1155/2014/437081 
  27. Ayeleso, A, Brooks, N, Oguntibeju, O (2014). Modulation of antioxidant status in streptozotocin-induced diabetic male Wistar rats following intake of red palm oil and / or rooibos. Asian Pacific Journal of Tropical Medicine, 536-544, doi: 10.1016/S1995-7645(14)60090-0 
  28. Ferreira Z, Ayeleso A, Mukwevho E (2014). Control of carbohydrate and lipid metabolism by NRF-1 and sirtuins: Implications on type 2 diabetes and obesity. Chemical Biology Letters, 1(2): 66-76 http://www.pubs.iscience.in/journal/index.php/cbl/article/view/144
  29. Ayeleso, AO, Oguntibeju, OO, Aboua YG, Brooks, NL (2014). Effects of red palm oil and rooibos on sperm motility parameters in streptozotocin-induced diabetic rats. African Journal of Traditional, Complementary and Alternative Medicine, 11(5): 8-15. doi: 10.4314/ajtcam.v11i5.2. PMID: 25395698; PMCID: PMC4202511.
  30. Mukwevho E, Ferreira Z, Ayeleso A (2014). Potential role of sulfur containing antioxidant systems in highly oxidative environments. Molecules, 19: 19376-19389. doi: 10.3390/molecules191219376. PMID: 25429562; PMCID: PMC6271769.
  31. Ayeleso, AO, Brooks, NL, Oguntibeju, OO (2013). Impact of dietary red palm oil (Elaeis guineensis) on liver architecture and antioxidant status in the blood and liver of male Wistar rats. Medical Technology SA, 27(2): 18-23. https://doi.org/10.4102/MTSA.V27I2.82
  32. Ayeleso, AO, Oguntibeju, OO, Brooks, NL (2013). Assessment on lipid profiles, antioxidant status and liver histopathology in male Wistar following dietary intake of rooibos (Aspalathus linearis). International Journal of Pharmacology, 9(6): 348-357. https://dx.doi.org/10.3923/ijp.2013.348.357
  33. Ayeleso, AO, Oguntibeju, OO, Brooks, NL (2012). Effects of dietary intake of red palm oil on lipid profile and fatty acid composition in male Wistar rats. African Journal of Biotechnology, 11(33): 8275-8279. https://doi.org/10.5897/AJB11.4080. -7.