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Lawrence ADEDAYO

Lecturer II
college of Health Sciences (COHES)
Physiology Programme

I have my doctoral degree in Neurophysiology at the University of Ibadan, Ibadan, Nigeria, where my research centered around investigating the intricate relationship between neuroinflammation, memory impairment, nociception and the potential therapeutic applications of nutritional plants in mouse models of neurobehavioral disorders. My undergraduate training was in Human Physiology from Amadu Bello University, Zaria, Nigeria. I currently teach physiological sciences courses to undergraduate medical and other allied Health sciences students. My primary career goal is to improve the quality of life through mental health and has incessantly fueled my studying of behavioural and molecular mechanisms underlying certain neuropsychiatry disorders and Alzheimer’s disease (AD).

Education
  • Ph.D. Neuroscience and Oral Physiology, 2023 (University of Ibadan, Ibadan, Nigeria)
  • M.Sc., Physiology, 2012 (University of Ibadan, Ibadan, Nigeria)
  • B.Sc., Human Physiology, 2009 ( Ahmadu Bello University, Zaria, Nigeria)
Research

Over the past decade, my research endeavors have been dedicated to the investigation of therapeutic nutritional plants with a focus on their potential applications in addressing central nervous system (CNS) disorders, particularly neurodegenerative diseases. This journey has encompassed a multifaceted exploration spanning haematology, toxicity, and metabolism in rodent and human models. The outcomes of these studies have unveiled a wealth of bioactive compounds within nutritional plants, distinguished by their non-toxic nature and their remarkable capacity to ameliorate various facets of health, including nociception, memory impairments, oxidative stress, haematological profiles, and both peripheral and CNS-related inflammatory responses in rodent and human subjects.

Specially, in one of my research projects with Buchholzia coriacea revealed the down-regulation of pro-inflammatory biomarkers. Immunohistochemistry investigations focusing on Nuclear factor kappa B (NF-kB), brain-derived neurotrophic factors (BDNF), and amyloid beta (Aβ) in a lipopolysaccharide-induced neuroinflammation murine model have underscored the remarkable potential of medicinal plant seeds to ameliorate these markers, as evidenced by our prior studies. Also, my research work on Cola nitida showed the anti-nociceptive potentials of the medicinal plants and mechanisms by which its mediate analgesic property.

Institutional Service
  • Level Adviser to100 level Physiology students 2016-2018
  • Level Adviser to 400 level Physiology students 2018-2020
  • Level Adviser to 400 level Intercalated Physiology 2019-2020
  • Seminar Coordinator for Final Physiology Students 2016-To date
  • Departmental curriculum review committee member 2017-2018
  • Admission screening committee member 2016-2020
  • Level Adviser to 200, level Physiology students 2020-2021
  • Level Adviser to 300, level Physiology students 2021-2022
  • Level Adviser to 400, level Physiology students 2023-To date
  • Member, Postgraduate Physiology Curriculum Committee 2022
  • Chairman, Physiology Programme Quality Assurance
  • Chairman, Welfare of Physiology Programme
  • University Representative for Admission Sensitization and Visitation Exercise to Secondary Schools in Kwara State in 2017
Professional Service
  • Neuroscience Society of Nigeria (NSN)
  • Society of Neuroscientists of Africa (SONA)
  • Member, Physiological Society of Nigeria
  • Movement Disorder Society (MDS)
  • The Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)
Selected Publications
  1. Adedayo LD, Ojo AO, Awobajo FO, Adeboye BA, Adebisi JA, Bankole TJ, Ayilara GO, Bamidele O, Aitokhuehi NG, Onasanwo SA (2019): Methanol extract of Cola nitida ameliorates inflammation and nociception in experimental animals, Neurobiology of pain (5) 100027
  2. Ozegbe Q.E.B, Obukohwo O.M, Aitokhuehi G.N., Fasanmade A.A., Adedayo L.D. and Oghenetega O.B. (2023).High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats. Songklanakarin J. Sci.Technol.45 (1), 131-137
  3. Bamidele O, Kolawole JT, Ayoka AO, Babatunde LD, Onaseso OO, and Adedeji GT (2017): Wound Healing Potentials of Aqueous Leaf Extract of Mangifera indica L. in Wistar Rats. Journal of complementary and Alternative Medical Research 2(4):1-11 
  4. Michael O.S., Bamidele O., Ogheneovo P. Ariyo T.A., Adedayo L.D., Oluranti O.I., Soladoye E.O, Adetunji C.O., Awobajo F.O. (2021): Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats. Current Research in Physiology (4) 252-259
  5. Bamidele O, Okeke NC, Adedeji TG, Adedayo LD and Akinnuga AM (2020): Methanol extract of Basella alba alleviate stress in rats. Chinese Herbal Medicine 12: 163-170
  6. Adedayo L.D., Offor G., Jolayemi O., Ojo G.B., Bamidele O., Ojo A.O., Emmanuel T.O., Aitokhuehi N., Onasanwo S.A., Ayoka A.O., (2021). Aripiprazole ameliorates scopolamine-induced amnesia in mice. J. Pharmacy and Bioresources 18(1),12-24
  7. Adedayo LD, Olawuyi DA, Ojo AO, Bamidele O. Onasanwo SA, Ayoka AO (2017): The Role of Aripiprazole (An Anti-psychotic Drug) in the Resolution of Acute Peripheral Inflammation in Male Wistar Rats. Journal of Pharmaceutical Research International 17 (6):1-8
  8. Onasanwo SA, Babatunde LD and Faborode OS (2016): Anti-Nociceptive and Anti-Inflammatory Potentials of Fractions from the leaf Extract of Tetracarpidium conophorum in Rats and Mice. African Journal of Biomedical. Research. (19):45-54 
  9. Lawrence ADEDAYO, Gideon OJO, Samuel UMANAH, Gideon AITOKHUEHI, Ileri-oluwa EMMANUEL, Olubayode BAMIDELE. (2023): Hippocampus: its roles in Relational memory. More Just a Memory. IntechOpen Publishers; DOI: http://dx.doi.org/10.5772/intechopen.111478
  10. Adedayo L.D, Bamidele O., Onasanwo S.A. (2022): Cola nitida and pain relief. Treatment, Mechanisms and Adverse Reactions of Anesthetics and Analgesic, Academic Press, First Edition, pp 375-384. http://www.elsevier.com/books-and-journals
  11. Ojo A.O., Ekomaye H.O., Owoade M.,Onaseso O.O., Adedayo L.D., Oluranti O.I., Emmanuel O.T., Ayoka A. (2021) The effect of ginger (Zingiber officinale) feed on cardiac biomarkers in medium-dose isoproterenol-induced myocardical toxicity. Avicenna J Phytomed. 11(1): 1-10