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Olumide ADELEKE

Associate Lecturer
college of Health Sciences (COHES)
Family Medicine Programme

A family physician, mission-minded administrator and clinical researcher with special interest in malariology, sickle cell diseases, mental health, patient-centred clinical method and Artificial intelligence.

Education
  • FWACP ( FM)- April, 2023. Bowen University Teaching Hospital. 
  • MBBS (Ib) – January, 2013. University of Ibadan
Research

Having cared for thousands of adults and children with infectious diseases like Malaria in Nigeria and seeing a number of them die or suffer life-long complications from these preventable and treatable conditions, I have been constantly thinking of research-driven solutions to the problems. I also strongly believe that there is an urgent need to train African researchers in providing solutions to the unacceptably high burden of communicable diseases in Sub-Saharan Africa. My desire to make a positive impact in the fight against infectious diseases of poverty through clinical trials and vaccine development is the basis of my application for this fellowship.

I have keen interest in clinical research and my life time dream is to be a world-class African research expert. My formative experience in medical school coupled with my family medicine residency training and practice has already laid, a solid foundation in understanding the scientific basis of infectious diseases and the care of patients, thereby making me an excellent candidate for the fellowship. Seeking to develop my skills further, I have attended many research-oriented workshops and training locally and nationally .I have also been privileged to be mentored by some local researchers and an international mentor; Prof. Tina M. Slusher. I was fortunate to be part of international research trials such as the Clinical Randomisation of an Antifibrinolytic in Significant Head injury (CRASH-3 Trial) and the Haemorrhage Alleviation with Tranexamic Acid – Intestinal System (HALT-IT).My main duties in the trials were to recruit eligible subjects, take informed consent, administer interventions in a double-blind manner, and collate study data. The experience allowed me to gain hands-on and further ignited my passion for clinical trials. I have since then been constantly longing for opportunities to develop myself further in clinical research skills and clinical research leadership experience.

My current research interest is in malaria especially malaria drugs and vaccine development. I was privileged to be awarded the prestigious American Academy of Pediatrics ICATCH Grant to execute a pilot project in Nigeria on malaria prevention in infants through the implementation of Intermittent Preventive Treatment with Sulphafoxine-Pyrimethamine (SP-IPTi) in the 2019 -2022 cycle of the grant. I sought the efficacy of Sulphafoxine-Pyrimethamine (SP) in preventing malaria incidence in infants but I discovered that the drug had no benefit in IPTi. I attributed this to the declining efficacy of SP, due to increasing drug resistance. The abstract of this cluster-randomized controlled trial won the American Pediatric Association 2022 Global Health Research Award and it was presented at the2022 Pediatric Association Society Conference in Denver, USA. The manuscript was recently published by the Tropical Journal of Pediatrics. I am highly committed to pursuing research-driving innovations and solutions to infectious diseases like malaria. I am also interested in vaccine development and the development of anti-snake venom.

Following the completion of the SP-IPTi trial, I am currently interested in understanding the level of antimalarial drug resistance in Nigeria and the protective efficacy of newer antimalarial drugs. This would help to guide policymakers in making evidence-based recommendations on the choice of antimalarial drugs for malaria chemoprevention and treatment of malaria in both children and adults especially vulnerable individuals such as pregnant women, infants, and sickle cell patients. I am also keenly interested in malaria vaccine development. It is sad to note that Nigerians are yet to benefit from malaria vaccine trials and vaccine administration since the launching of the RTS, S/AS01 vaccine by the World Health Organization on October 6, 2021. Nigerian researchers are urgently needed in vaccine development.

Institutional Service
  • Deputy Director of Health Services. 
  • Member, University Convocation Planning Committee.
  • Board Member, Bowen University International Staff School.
Professional Service
  • Reviewer, 2023 Heliyon.
  • Reviewer, 2024 PAS Conference.
Selected Publications
  1. Adeleke OT, Oyenuga A, Slusher TM, Gbadero DA. Cluster-randomized controlled trial of intermittent preventive treatment in infancy using sulfadoxine–pyrimethamine (SP-IPTi): a pilot study in Nigeria. Journal of Tropical Pediatrics. 2023 Feb;69(1):fmad001.
  2. Slusher TM, Vreman HJ, Brearley AM, Vaucher YE, Wong RJ, Stevenson DK, Adeleke OT, Ojo IP, Edowhorhu G, Lund TC, Gbadero DA. Filtered sunlight versus intensive electric powered phototherapy in moderate-to-severe neonatal hyperbilirubinaemia: a randomised controlled non-inferiority trial. The Lancet Global Health. 2018 Oct 1;6(10):e1122-31. 3. 
  3. Adeleke, OT (2022). Performing Lumbar Puncture in a Low-Resource Setting. In: Slusher, T.M., Bjorklund, A.R., Lauden, S.M. (eds) Pediatric Procedural Adaptations for Low-Resource Settings. Springer, Cham. https://doi.org/10.1007/978-3-030-99955-1_20
  4. Ojeniyi DA, Olumide A, Abel AM, Olusayo AI, Adesope A. Neonatal Urinary Outflow Obstruction Requiring Early Circumcision. AJCRS [Internet]. 2019 Sep. 3 [cited 2023 Feb. 18];2(3):1-5. Available from: https://journalajcrs.com/index.php/AJCRS/article/view/7
  5. Alao MA, Olasinde YT, Gbadero DA, Tongo OO, Adeleke OT, Slusher TM. Aetiology of neonatal jaundice in apparently well late-preterm and term neonates at a mission hospital, Southwestern Nigeria. Nigerian Journal of Paediatrics. 2022 May 2;49(1):27-32..
  6. Adeleke, O.T (2012). Recent Technological Advances in the Management of Infectious Diseases. In:Adebanji. A. B, ken N. A (eds). Infections Contemporary Management. Book Builders, Africa.
  7. A Adegoke, A OlaOlorun, S Adesina, I Amole, E Idowu, T Adeleke, O.Awotunde. Prevalence and Sociodemographic Correlates of Anxiety and Depression in Ogbomoso, Nigeria.HEALTH SCIENCES AND DISEASE 24 (8), 2023.
  8. TO Adeleke, AO Durodola, MO Oyelami, IA Okunade, SI Oloruntoba. Penile Fracture following Penile Manipulation during Nocturnal Penile Tumescence-A Case Report. West African Journal of Medicine 40 (6), 663-665, 2023.
  9. TM Slusher, H Vreman, A Brearley, O Adeleke, Y Vaucher, R Wong, D. Gbadero. Filtered sunlight phototherapy, a novel treatment for moderate-severe hyperbilirubinemia, is no less efficacious than conventional phototherapy in neonates in ogbomoso, Nigeria. Pediatrics 142 (1_MeetingAbstract), 513-513, 2018.
  10. Adegoke, A. O., Adesina, S. A., Amole, I. O., Adeleke, O. T., Idowu, A. E., Akinwumi, A. I., OlaOlorun, A. D. (2023). Perceived Social Support And Associated Factors Among Adult HIV Patients At Bowen University Teaching Hospital (BUTH), Ogbomoso. The Journal of Middle East and North Africa Sciences, 9(10), 1-6]. (P-ISSN 2412- 9763) – (e-ISSN 2412-8937)