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Rufus AKOMOLAFE

Professor (Sabbatical)
college of Health Sciences (COHES)
Physiology Programme

A Professor of Renal and Gastrointestinal Physiology with years of experience and has successfully trained four PhD students, numerous masters and undergraduate students. I served as Vice Dean of Faculty of Basic Medical Sciences for two years and equally as representative of Faculty of Basic Medical Sciences on the Board of Postgraduate College in Obafemi Awolowo University, Ile-Ife for six consecutive years, among my other contributions to teaching, research, mentoring and community services.

Education
  • Bachelor of Science (B.Sc.) in Physiology 1983
  • Master of Science (M.Sc.) in Physiology 2001
  • Doctor of Philosophy (Ph.D) in Physiology 2005
Research

Renal and Gastrointestinal Physiology

Institutional Service
  • Member of the Senate, teaching and supervision of undergraduate and postgraduate students.
Professional Service
  • Chairman NUC Accreditation Team.
Selected Publications
  1. Akomolafe R.O., Adeoshun I.O., Ayoka A.O., Elujoba A.A., Iwalewa E.O. (2003) An in vitro study of the effects of Cassia sieberiana leaves extracts on the intestinal motility of rats. African Journal of Biomedical Research 6: 141 – 145.
  2. Akomolafe R.O., Adeoshun I.O., Ayoka A.O., Elujoba A.A., Iwalewa E.O. (2004) An in vitro study of the effects of Cassia podocarpa fruit on the intestinal motility of rats. Phytomedicine 11: 249 – 254.
  3. Akomolafe R.O., Adeoshun I.O., Ayoka A.O., Elujoba A.A., Iwalewa E.O. (2004) Effects of Cassia podocarpa leaves extracts on the rat ileum and colon (in vitro) BoletinLatinoamericano Y Del Caribe De PlantasMedicinales Y Aromaticas (Bulletin of Latin America and Carribean on Medicinal and Aromatic Plants) 3: 52 – 57. 
  4. Ayoka A.O.; Akomolafe R.O., Iwalewa E.O.; Ukponmwan O.E. (2005) Studies on the anxiolytic effect of Spondiasmombin L. (Anacardiaceae) extracts. African Journal of Traditional, Complementary and Alternative Medicine, 2: 153 – 165.
  5. Ayoka A. O, Akomolafe R.O, Iwalewa E. O., Akanmu M. A., Ukponmwan O. E. (2006) Sedative, antiepileptic and antipsychotic effects of Spondiasmombin L. (Amacardiaceae) in mice and rats. Journal of Ethnopharmacology. 103: 166 -175. 
  6. Akomolafe R. O., Adeoshun I. O., Fakunle J. B., Iwalewa E. O.,. Ayoka A. O, Akanji B. O. (2006) Changes in visceral functions of Plasmodium berghei infected and uninfected rats following administration of artemether. Clinical and Experimental Pharmacology and Physiology. 33: 1180-1183.
  7. Oyemitan I. A., Iwalewa E.O., Ukponmwan O. E., Akomolafe R.O. Daniyan O. M. (2007) The involvement of serotonin in artemether-induced behavioural activities. Journal of Biological Sciences. 7: 575-578. 
  8. Ayoka A. O. Akomolafe R. O. Akinsomisoye O. S. Ukponmwan O. E. (2008) Medicinal and Economic Values of Spondias mombin.African Journal of Biomedical Research. 11 129 – 136.
  9. Ajayi O. E. Abiola – Peller M. Abiona T. C. Akintomide A. O. Akomolafe R. O. Bamitale K. D. S. (2008). The Influence of Weight in the Non-Obese Range on Blood Pressure among Nigerian Undergraduates at Ile – Ife. The Nigerian Journal of Health Sciences. 8: 1 29 – 31.
  10. Akomolafe R.O., Adeoshun I.O, Fakunle J. B., Iwalewa E.O., Ayoka A.O., Ajayi O. E., Odeleye O. M., Akanji B. O.. (2011) Effect of artemether on the plasma and urine concentrations of some electrolytes in rats. African Journal of Biotechnology. 10: 4226-4233.
  11. Akomolafe R, O., Bamitale K. D. S., Iwalewa E. O. Adeniyi O. S., Ayoka A. O. (2011). Effects of aqueous Anaphe venata Extract on Fecal Pellet Output in Mice. International Journal of Biological and Chemical Sciences. 5: 2371-2381. 
  12. Akomolafe R.O., Adeoshun I.O,, Fakunle J. B., Iwalewa E.O., Ayoka A.O., Ajayi O. E., Odeleye O. M., Akanji B. O. (2011) Changes in Some Biochemical Parameters of Kidney Functions of Plasmodium berghei Infected Rats Administered with Some Doses of Artemether. African Journal of Biotechnology. 11: 7119-7127.
  13. Akomolafe R. O., Adeoshun I.O, Fakunle J. B., Iwalewa E.O., Ayoka A.O., Ajayi O. E., Odeleye O. M., Akanji B. O. (2013) Effects of artemether on biochemical markers of liver function in Plasmodium berghei-infected and non-infected rats. African Journal of Biotechnology. 12:1275-1287.
  14. Abiodun O Ayoka, Rotimi A Owolabi, Samuel K Bamitale, Rufus O Akomolafe, Joseph A Aladesanmi Eghe O Ukponmwan (2013) Effects of Fractionated Extracts and Isolated Pure Compounds of Spondias Mombin (L. Anacardiaceae) Leaves on Novelty-Induced Rearing and Grooming Behaviours in Mice. African Journal of Traditional Complementary and Alternative Medicine 10:244-255.
  15. Ayoka O A, Owolabi A R, Bamitale K S, Akomolafe O R, Aladesanmi J A, Ukponmwan O E (2013) Effects of Fractionated Extracts and Isolated Pure Compounds of Spondias (L. Anacardiaceae) Leaves on Gross Exploratory Behaviors in mice. Nigerian Journal of Natural Product and Medicine 17: 66 – 76.
  16. Olaoluwa S. Olukiran, Rufus O. Akomolafe, Kayode D. Bamitale, Akande O. Ajayi, Raphael E. Okonji, Ronald D. Bejide (2014) Protective and Curative Effects of Livolin forte on Carbon Tetrachloride-Induced Liver Damage in Wistar Rats. Journal of Experimental and Integrative Medicine 4: 57-65.
  17. Olukiran S Olaoluwa, Rufus O Akomolafe, Kayode D Bamitale, Akande O Ajayi, Raphael E Okonji, Ronald A Bejide. (2014). Prophylactic and Curative Assessment of Essential Forte on Carbon Tetrachloride – Induced Liver Damage in Wistar Rats.Macedonian Journal of Medical Sciences 7: 408 – 414.
  18. Adeniyi O. S., Akomolafe R. O., Ojabo C. O., Eru E. U., Olaleye S.B.(2014) Effects of zinc treatment on intestinal motility during diarrhea. Nigerian Journal of Physiological Sciences 29:11 – 15. 
  19. Ayoka A.O, Ogunlade O, Akintomide A.O, Akomolafe R.O, Ajayi O.E (2014) Normal Limits of Electrocardiogram and Cut-off Values for Left Ventricular Hypertrophy in Young Adult Nigerians. Nigerian Journal of Physiological Sciences 29: 63 – 66.
  20. Rufus O. Akomolafe, Olaoluwa S. Olukiran, Chris E. Imafidon, Olugbenga A. Ayannuga, John A. Oyekunle, Babatunde O. Akanji, Ayowole A. Oladele (2014) A Study of Two weeks Administration of Copper Sulphate on Markers of Renal Function and Feeding Pattern of Wistar Rats. African Journal of Biochemistry Research 8 (9) 158 – 165. 
  21. Rufus O. Akomolafe, Olusoji A. Adalumo, Kayode D. S. Bamitale (2014). Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. American Journal of Life Sciences 2(6) 406 – 412.  
  22. O Ogunlade, AO Ayoka, A Akintomide, RO Akomolafe, OS Akinsomisoye, DO Oyebola (2015). Non-invasive Assessment of Cardiac Autonomic Functions in Healthy Young Adults in Ile Ife, South-Western Nigeria. International Journal of Clinical Cardiology 2:3
  23. OS Osuntokun, G Olayiwola, OA Adalumo, OS Olaoluwa, RO Akomolafe (2016. Medicinal Plants in the Treatment of Diarrhea: A Review of Phytochemistry and Pharmacology. UNIOSUN Journal of Science 1(2)
  24. Oluwadare Ogunlade, Abiodun O. Ayoka, Rufus O. Akomolafe, Olumide S. Akinsomisoye, Abebayo Irinoye,Adewale Ajao,Muritala A. Asafa (2015).The Role of Electrocardiogram in the Diagnosis of Dexrocardia with Mirror Image Atrial Arrangement and Ventricular Position in a Young Adult Nigerian in IIe-Ife: A Case Report. Journal of Medical Case Report 9:242. 
  25. Christian E. Imafidon, Rufus O. Akomolafe, Abubakar A. Sanusi, Oluwadare J. Ogundipe, Olaoluwa S. Olukiran, Oladele A. Ayowole (2015). Polyphenol­ rich Extract of Vernonia amygdalina (Del.) Leaves Ameliorated Cadmium­ induced Alterations in Feeding Pattern and Urine Volume of Wistar Rats. Journal of Intercultural Ethnopharmacology 4: 284 – 292.
  26. Christian E. Imafidon, Rufus O. Akomolafe, Abubarkar A. Sanusi, Oluwadare J. Ogundipe, Olaoluwa S. Olukiran, Oladele A. Ayowole (2015).Amelioration of Cadmium-induced Nephropathy using Polyphenol-rich Extract of Vernonia amygdalina (Del.) Leaves in Rat Model. Macedonian Journal of Medical Sciences. 120: I – II.
  27. Rufus O. Akomolafe, Olusoji A. Adalumo, Kayode D. S. Bamitale (2015). Gabaergic Potentiation of Reduced Bowel Movements, Induced with Zinc Sulphate by Baclofen. Fiziologia – Physiology 4: 47 – 53.
  28. Dare J. Ogundipe, Rufus O. Akomolafe, Abubarkar A. Sanusi, Christian E. Imafidon, Olaoluwa S. Olukiran, Oladele A. Ayowole (2016). Effect of Two Weeks Administration of Ocimum gratissimum Leaf on Feeding Pattern and Markers of Renal Function in Rats Treated with Gentamicin. Egypitan Journal of Basic and Applied Sciences 3: 219 – 231. 
  29. Rufus O. Akomolafe, Olaoluwa S. Olukiran, Christian E. Imafidon, Olugbenga A. Ayannuga, John A. Oyekunle, Ayowole A. Oladele (2016). Effects of Chronic Copper Sulphate Administration on Feeding Pattern and Markers of Renal and Liver Functions of Wistar Rats. Fiziologia – Physiology 1: 13 -19.
  30. Rufus O. Akomolafe, Christian E. Imafidon, Olaoluwa S. Olukiran, Ayowole I. Oladele, Akande , A. O. Ajayi (2016). Livolin Forte Ameliorates Cadmium­ induced Kidney Injury in Wistar Rats. Serbian Journal of Experimental and Clinical Sciences 17: 107 – 116.
  31. Olaleye R. O., Akomolafe R. O., Imafidon E. C., Ogudipe D. J., Olukiran S.O., Oladele A. A. (2016). Treatment with Methanolic Extract of Ocimum gratissimum (Linn.) Leaf Reversibly Normalizes Urine Protein-creatinine Ratio in Wistar Rat Model of Gentamicin-induced Kidney Injury. International Journal of Medicine and Biomedical Research 5:155 -171
  32. Eseigbe C. Imafidon, Rufus O. Akomolafe, Abraham A. Ayowole (2016). Sexually Dimorphic Proteinurai in Wistar Rats: Relevance to Clinical Models. Pathophysiology 23: 51 -59.
  33. Mirian N. Ashibuogwu, Olukayode I. Adeosun, Rufus O. Akomolafe, Douglas O. Sanni, Olaoluwa S. Olukiran (2016). Diuretic Activity and Toxicity study of the Aqueous Extract of Cola nitida Seed on Markers of Renal Function and Electrolytes in Rats. Journal of Complementary and Integrative Medicine 13(4) 393 – 404.
  34. Dare J. Ogundipe, Rufus O. Akomolafe, Abubarkar A. Sanusi, Christian E. Imafidon, Olaoluwa S. Olukiran, Oladele A. Ayowole (2017). Ocimum gratissimum Ameliorates Gentamicin-induced Kidney Injury but Decreases Creatinine Clearance following Sub-chronic Administration in Rats. Journal of Evidence-based Complementary and Alternative Medicine 1 -11.
  35. Mosunmola B. Omotola, Isaac O. Adeosun, Efere M. Obuotor, Rufus O. Akomolafe, Olugbenga A. Ayannuga (2017). Assessment of the Effects of Graded Doses of Polyphenol-rich Fraction of Garcinia kola Seeds on Pituitary-Testicular Axis of Male Wistar Rats. Dose Response: An International Journal DOI: 10.1177/1559325817729260.
  36. Quadri K. Alabi, Rufus O. Akomolafe, Olaoluwa S. Olukiran, Aliyat O. Nafiu, Joseph G. Omole, Adebukola M. Adefisayo, Ayowole A. Oladele (2017). Assessment of Haematological and Biochemical Effects of Kolaviron in Male Wistar Rats. British Journal of Pharmaceutical Research 16(3) 1 – 14.
  37. Quadri K. Alabi, Rufus O. Akomolafe, Olaoluwa S. Olukiran, Wale J. Adeyemi, Aliyat O. Nafiu, Modinat A. Adefisayo, Joseph G. Omole, Deborah I. Kajewole, Oluwole O. Odujoko (2017). The Garcinia kola Biflavonoid Kolaviron Attenuates Experimental Hepatotoxicity Induced by Diclofenac. Pathophysiology 24: 281 – 290.
  38. Moidinat A. Adefisayo, Rufus O. Akomolafe, Stephen O. Akinsomisoye, Qudri K. Alabi, Olaofe L. Ogundipe, Joseph G. Omole, Kehinde P. Olamilosoye (2017). Gastroprotective Effects of Methanol Extract of Vernonia Amygdalina (Del.) Leaf on Aspirin-induced Gastric Ulcer in Wistar Rats. Toxicology Reports 4:625-633.
  39. Alabi Q.K., Akomolafe R.O., Olukiran O.S., Nafiu A.O., Adefisayo M.A., Owotomo O.I., Omole J.G. and Olamilosoye K.P. (2018). Combined administration of L-carnitine and ascorbic acid ameliorates cisplatin-induced nephrotoxicity in rats. Journal of the American College of Nutrition; 37(5): 387 – 398.
  40. Alabi Q.K., Akomolafe R.O., Adefisayo M.A., Olukiran O.S., Nafiu A.O., Fasanya M.A., Oladele A.A. (2018). Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats. Applied Physiology, Nutrition, and Metabolism. 43(9): 956-968.  
  41. Olukiran O.S., Akomolafe R.O., Ilesanmi O.S., Imafidon C.E. and Alabi Q.K. (2018). Age‐related changes in urinary protein excretion in relation to indices of renal function in Wistar rats. Animal Model and Experimental Medicine (Wiley & Sons); (4):295–304.
  42. MA. Adefisayo, RO. Akomolafe, OS. Akinsomisoye, QK. Alabi, L., Ogundipe, JG., Omole, KP., Olamilosoye (2018). Protective effects of methanol extract of Vernonia amygdalina (del.) leaf on aspirin-induced gastric ulceration and oxidative mucosal damage in a rat model of gastric injury. Dose-Response. 16(3). 1-11. DOI: 10.1177/1559325818785087. SAGE.
  43. KP. Olamilosoye, RO. Akomolafe, OS. Akinsomisoye, MA. Adefisayo, QK. Alabi. (2018). The Aqueous extract of Ocimum gratissimum leaf ameliorates acetic acid induced colitis in male Wistar rats. Egyptian Journal of Basic and Applied Sciences. 5:220–227 DOI: 10.1016/j.ejbas.2018.05.006. – Elsevier. 
  44. QK. Alabi, RO. Akomolafe, JG. Omole, MA., Adefisayo, L., Ogundipe, A., Aturamu, J O., Sanya. (2018). Polyphenol-rich extract of Ocimum gratissimum leaves ameliorates colitis via attenuating colonic mucosa injury and regulating pro-inflammatory cytokines production and oxidative stress. Biomedicine and pharmacotherapy. 103:812–822. Elsevier Masson SAS. 
  45. EO Oyetola, RO Akomolafe, FJ Owotade, S Egunjobi (2018). Physio-Chemical Analysis of Unstimulated Saliva of Healthy Nigerian Population. Journal of Oral Biology 5(6)
  46. Olukiran O.S., Akomolafe R.O., Ilesanmi O.S., Imafidon C.E. and Alabi Q.K (2019). Proteinuria in relation to age-dependent changes in the plasma and urine concentrations of some electrolytes and hematological indices in Wistar rats. Veterinary and Animal Science (Elsevier); 7(2019): 100048.
  47. Imafidon C.E., Akomolafe R.O., Eluwole O.A., Adekunle I.A., Agbaje R.A. (2019). Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier. Clinical Phytoscience, Springer. 5(27): 1–13. https://doi.org/10.1186/s40816-019-0118-y (Switzerland). 
  48. QK Alabi, RO. Akomolafe. (2019). Kolaviron diminishes diclofenac induced liver and kidney toxicity in Wistar rats via suppressing inflammatory events, up-regulating antioxidant defenses and improving hematological indices. Dose Response. 1-12. DOI: 10.1177/1559325819899256. SAGE.
  49. A. O. Nafiu, RO. Akomolafe, QK. Alabi., CO., Idowu, OO., Odujoko (2019). Effect of fatty acids from ethanol extract of Moringa oleifera seeds on kidney function impairment and oxidative stress induced by gentamicin in Rats. Biomedicine and Pharmacotherapy. 117: 109154. Elsevier.
  50. QK Alabi, CE. Imafidon, RO Akomolafe. (2019) Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. Journal of Complementary Medicine Research. 10(1):58-67.
  51. Imafidon C.E, Akomolafe R.O. (2019). Obesity-induced renal injury is associated with oxidative stress via ischemia reperfusion injury. Obesity Medicine, Elsevier. 14 (2019) 100093. https://doi.org/10.1016/j.obmed.2019.100093
  52. Imafidon C.E., Akomolafe R.O., Oke G.O. (2020). Saliva renal function biomarkers as alternatives to plasma concentrations in obesity-induced kidney injury. Obesity Medicine, Elsevier. 17 (2020) 100195. https://doi.org/10.1016/j.obmed.2020.100195.
  53. Oghobase GE, Aladesanmi OT, Akomolafe RO, Olukiran OS, Akano PO Eimunjeze MH, (2020). Assessment of the toxicity and biochemical effects of detergent processed cassava on renal function of Wistar rats. Toxicology Reports (2020) 1103-1111. 
  54. Alabi QK, Akomolafe RO, Omole GJ Aturamu A, Ige MS, Kayode OO, Kajewole DI (2021). Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats. BMC Complementary Medicine and Therapies 21: 274.
  55. OJ Ogundipe, RO Akomolafe, OS Olukiran, OF Akinpelu (2022). Obesity and Maternal Lipid Profile: Role of Diet in Epigenetic Transfer on the Offspring. American Journal of Health Research 10(1) 8-12.
  56. QK Alabi, RO Akomolafe (2022). Novel Sedentary Cage Induced Sedentariness in Rats: Evidence from Relevant Biomarkers. BMC Endocrine Disorders 22(1) 1-13

Manuscripts Submitted for Publication: 

  1. B. Emma-Okon, R. Akomolafe, O Ayannuga, M. Tombs (2023). Teaching Pre-clinical Students Remotely in Nigeria Post Covid-19 Pandemic: Can Past Experiences Shape Future Directions? BMC Medical Education

These and Degree Project(s):

  1. The effects of Boerhavia diffusa on the smooth muscle of the rat. B.Sc. Physiology Dissertation (November, 1983) submitted in partial fulfilment for the award of B.Sc. degree in Physiology.
  2. An in-vitro study of the physiological effects and mechanisms of action of some Nigeria Cassia species on the motility of the ileum and colon of Albino Wistar rats. M.Sc. Thesis (August, 2001) submitted in partial fulfilment for the award of M.Sc. degree in Physiology.
  3. A study of histophysiological and metabolic activities of artemether in normal and malaria-infected Rattus norvegicus (Wistar rats). Ph.D. Thesis (July, 2005) submitted in partial fulfilment for the award of Ph.D. degree in Physiology.